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[PDF] Cocrystal solubility-pH and drug solubilization ...

This review discusses the disposition of the anionic surfactant, sodium dodecyl sulfate (SDS; i.e., sodium lauryl sulfate), to solubilize sparingly-soluble drugs above the surfactant critical micelle concentration (CMC), as quantitated by the solubilization capacity (k). A compilation of 101 published SDS k values of mostly poorly-soluble drug molecules was used to develop a prediction model ...
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(PDF) Solution-Mediated Phase Transformation of ...

Solution-Mediated Phase Transformation of Haloperidol Mesylate in the Presence of Sodium Lauryl Sulfate
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(PDF) Cocrystal solubility-pH and drug solubilization ...

Cocrystal solubility-pH and drug solubilization capacity of sodium dodecyl sulfate - Mass action model for data analysis and simulation to improve design of experiments
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The effect of surfactant and polymer on solution …

The thermodynamic solubility of cocrystal was determined in phosphate buffer solution (pH = 6.8) and in the presence of different concentrations of sodium lauryl sulfate (SLS) and polyvinylpyrrolidone (PVP), followed by investigating their effects on solution stability of cocrystal.
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Engineering Cocrystal Solubility, Stability, and pH(max ...

Engineering Cocrystal Solubility, Stability, and pH(max) by Micellar Solubilization ... (max) of carbamazepine cocrystals in micellar solutions of sodium lauryl sulfate predicted by the models are ...
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16 · 1 :, Crystal Pharmatech Email:[email protected] : 69561921
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Engineering cocrystal solubility, stability, and pH(max ...

6 · The solubility, CSC, and pH(max) of carbamazepine cocrystals in micellar solutions of sodium lauryl sulfate predicted by the models are in very good agreement with experimental measurements. The findings from this work demonstrate that cocrystal CSC and pH(max) can be tailored from the selection of coformer and solubilizing additives such as ...
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Engineering cocrystal solubility and stability via ...

Cocrystal solubility, stability, and eutectic points were investigated as a function of pH and sodium lauryl sulfate concentration for a series of carbamazepine cocrystals in water. The cocrystals represented two stoichiometries (1:1 and 2:1) and four coformers (salicylic acid, saccharin, aminobenzoic acid, and succinic acid) with various ...
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Investigation of Ternary Phase Diagrams of …

The phase diagrams for carbamazepine (CBZ) and nicotinamide (NCT) in ethanol and ethanol/ethyl acetate mixture were constructed at 298.15 K and 313.15 K under atmospheric pressure using the static method. The solubility of the 1:1 cocrystal is correlated as a function of the cocrystal former (nicotinamide) concentration by a mathematical model based on solubility product theory and the ...
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Cocrystal solubility-pH and drug solubilization …

Cocrystal solubility-pH and drug solubilization capacity of sodium dodecyl sulfate – mass action model for data analysis and simulation to improve design of experiments. Alex Avdeef; in-ADME Research, 1732 First Avenue #102, New York, NY 10128 USA
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Cocrystal solubility-pH and drug solubilization …

This review discusses the disposition of the anionic surfactant, sodium dodecyl sulfate (SDS; i.e., sodium lauryl sulfate), to solubilize sparingly-soluble drugs above the surfactant critical micelle concentration (CMC), as quantitated by the solubilization capacity (k).
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Effect of Micellar Solubilization on Cocrystal Solubility ...

12 · Engineering cocrystal solubility, stability, and pHmax by micellar solubilization. Journal of Pharmaceutical Sciences 2011, 100 (12) , 5234. DOI: 10.1002/jps.22725. Kristyn Greco, Robin Bogner. Solution-Mediated Phase Transformation of Haloperidol Mesylate in the Presence of Sodium Lauryl …
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CiteSeerX — Article Influence of Sodium Lauryl Sulfate …

BibTeX @MISC{Li13articleinfluence, author = {Mingzhong Li and Ning Qiao and Ke Wang}, title = {Article Influence of Sodium Lauryl Sulfate and Tween 80 on Carbamazepine–Nicotinamide Cocrystal Solubility and Dissolution Behaviour}, year = {2013}}
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A commonly used pharmaceutical surfactant, sodium lauryl sulfate (SLS), has been reported to reduce the dissolution rate of drugs due to the formation of a less soluble drug-lauryl sulfate salt ...
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Cocrystal solubility advantage diagrams as a means to ...

Experimental results with indomethacin-saccharin cocrystal (IND-SAC) and surfactants (sodium lauryl sulfate, Brij, and Myrj) demonstrate the log-linear relationship characteristic of SA - SP ...
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Influence of Sodium Lauryl Sulfate and Tween 80 on ...

The influence of the surfactants of sodium lauryl sulfate (SLS) and Tween 80 on carbamazepine–nicotinamide (CBZ–NIC) cocrystal solubility and dissolution behaviour has been studied in this work. The solubility of the CBZ–NIC cocrystal was determined by measuring the eutectic concentrations of the drug and the coformer. Evolution of the intrinsic dissolution rate (IDR) of the …
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Influence of sodium lauryl sulfate and Tween 80 on ...

Citation : Li, M., Qiao, N. and Wang, K. (2013) Influence of Sodium Lauryl Sulfate and Tween 80 on Carbamazepine–Nicotinamide Cocrystal Solubility and Dissolution Behaviour. Pharmaceutics. 5 …
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Influence of sodium lauryl sulfate and tween 80 on ...

11 · The influence of the surfactants of sodium lauryl sulfate (SLS) and Tween 80 on carbamazepine-nicotinamide (CBZ-NIC) cocrystal solubility and dissolution behaviour has been studied in this work. The solubility of the CBZ-NIC cocrystal was determined by measuring the eutectic concentrations of the drug and the coformer.
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Cocrystal Solubility Advantage Diagrams as a Means …

25 · Experimental results with indomethacin-saccharin cocrystal and surfactants (sodium lauryl sulfate, Brij, and Myrj) demonstrate the log-linear relationship characteristic of SA–SP diagrams and the dependence of σmax and dissolution area under the curve (AUC) on SA with characteristic maxima at a threshold supersaturation where drug nucleation ...
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WO2010011926A2

The invention relates to a novel betaine cocrystal of [(lZ,2E) -methyl - phenylpropenylidene] -oxo -thioxo -thiazolidineacetic acid. The preparation and characterization of the novel betaine cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel betaine cocrystal and the therapeutic use of ...
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Engineering cocrystal thermodynamic stability and …

Predictions are in excellent agreement with the behavior of several carbamazepine cocrystals in aqueous solutions of sodium lauryl sulfate. Increasing the magnitude of micellar solubilization for one of the cocrystal components is found to confer greater thermodynamic stability to the cocrystal and expand its …
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US8871793B2

US8871793B2 US13/518,13518177A US8871793B2 US 8871793 B93 B2 US 8871793B2 US 201013518177 A US201013518177 A US 201013518177A US 8871793 B93 B2 US 8871793B2 Authority US United States Prior art keywords metaxalone cocrystal 2θ acid cocrystal powder Prior art date 23 Legal status (The legal status is an assumption and is not a legal …
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Influence of Sodium Lauryl Sulfate and Tween 80 on ...

The influence of the surfactants of sodium lauryl sulfate (SLS) and Tween 80 on carbamazepine–nicotinamide (CBZ–NIC) cocrystal solubility and dissolution behaviour has been studied in this work. The solubility of the CBZ–NIC cocrystal was determined by measuring the eutectic concentrations of the drug and the coformer.
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(PDF) Influence of Sodium Lauryl Sulfate and Tween …

The influence of the surfactants of sodium lauryl sulfate (SLS) and Tween 80 on carbamazepine-nicotinamide (CBZ-NIC) cocrystal solubility and dissolution behaviour has been studied in this work.
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